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What condition does Rasburicase treat?

Rasburicase is used to prevent high blood levels of uric acid from occurring. This is usually recommended in children with cancer who are about to receive cancer chemotherapy treatment. A type of cancer may include leukemia, lymphoma, and solid malignant tumors. Once chemotherapy is given, the cancer cells are being destroyed. It releases a large amount of uric acid into the bloodstream.

Rasburicase is in the group of drugs called enzymes. This medication allows uric acid to more easily be removed from the body. It is by the kidneys. The Food and Drug Administration (FDA) approved this medication.

How does Rasburicase work?

Rasburicase catalyzes enzymatic oxidation of poorly soluble uric acid into an inactive and more soluble metabolite (Allantoin). This medication works by breaking down uric acid so that the body can eliminate it.

What is the recommended dosage of Rasburicase?

This medication is given by injection into a vein. It is usually given over 30 minutes or as directed by your doctor. It is given once a day for 5 days. Chemotherapy is usually started 4 to 24 hours after the first dose of this medication.

If you do not know how to use it, ask for the assistance of your doctor. Follow the instructions very carefully.

If you missed a dose, call your doctor for instructions. Do not have two doses to make up for the missed one. This medication should be given regularly for the best benefit. It is important to inform your doctor if your condition does not improve or if it gets worse.

What are the side effects of Rasburicase?

  • Nausea
  • Headache
  • Vomiting
  • Constipation
  • Stomach pain
  • Fever
  • Diarrhea
  • Anxiety
  • Mouth sores
  • Ulcer
  • Sore throat
  • Rash
  • Swelling in your hands or feet

Call your doctor bright away if these serious side effects happen:

  • Fever
  • Persistent sore throat
  • Chills
  • Weakness
  • Chest pain
  • Severe dizziness
  • Trouble breathing
  • Yellowing eyes and skin
  • Dark urine

What are the precautions in taking Rasburicase?

  • This drug must only be used when needed during pregnancy. Discuss the benefits of this drug as well as the risks with your doctor before using this medication.
  • Tell to your doctor if you ever had an allergic reaction to it or if you have any allergies. Tell also your doctor if you have any medical history or any current medications.
  • Caution is advised when using this medication in children less than 2 years old. They may be more sensitive to the side effects of this drug.
  • Do not breastfeed while using this medication or for at least 2 weeks after your last dosage. If you are a breastfeeding woman, consult your doctor first before taking this drug.
  • If you are having surgery including dental surgery, tell the doctor or dentist that you are receiving this medication.
  • Let your doctor and pharmacist know what other non-prescription and prescription medications, nutritional supplements, vitamins, and herbal products you are taking or plan to take. Your doctor might need to change the dosages of your medicines or monitor you cautiously for side effects.