General Information

Persantine (Dipyridamole) is used in combination with ‘blood thinners’ like warfarin. It is to keep clots from forming after heart valve replacements. Clots are a serious complication that can cease heart attacks and strokes. It may also cause blocked blood vessels in the lungs or called pulmonary embolisms. The combination of medications lessens the chance of a clot forming on the valve.

 

How does Persantine (Dipyridamole) work?

Persantine (Dipyridamole) prevents blood cells called platelets from clumping together inside the blood vessels. It is sometimes referred to as a ‘blood thinner’ and dilates the blood vessels.

This drug works by blocking the action of an enzyme found in platelets called phosphodiesterase. Inside the platelets phosphodiesterase normally breaks down a chemical called cyclic AMP. Cyclic AMP plays a key role in blood clotting. If the level of cyclic AMP in the platelets is high this prevents the platelets from clumping together. This medication causes the levels of cyclic AMP in the platelets to rise because it stops phosphodiesterase from breaking it down. This means that this drug stops the platelets from clumping together and causing a blood clot.

Why use Persantine (Dipyridamole)?

Persantine (Dipyridamole) is considered as an antiplatelet drug. This is available as tablets for oral administration with the strengths of 25mg, 50mg, and 75mg. this prescription contains Dipyridamole as an active ingredient. The Food and Drug Administration (FDA) approved this medication.

How to use Persantine (Dipyridamole)?

The recommended dosage is based on your medical condition and response.

This drug is usually taken 4 times a day. It is to be taken by mouth with a full glass of water. It is best taken on an empty stomach but it may be taken with meals if stomach upset occurs.

Take it at the same time each day. Do not use longer or more often than prescribed. You should not stop or change the dose and dosing schedule without talking with your doctor.

What are the side-effects of Persantine (Dipyridamole)?

• Diarrhea
• Dizziness
• Stomach upset
• Headache
• Flushing
• Vomiting
• Skin rash or itching
• Muscle or joint pain

Call your doctor right away if these happen:

• Stomach pain
• Fainting
• Dark urine
• Yellowing eyes or skin
• Unusual bleeding or bruising

Warnings and Precautions

• Do not take this if you are allergic to it. Let your doctor know if you have any allergies.
• This is only prescribed when needed for pregnant women. If you are breastfeeding, talk to your doctor first.
• Inform your doctor if you have any medical history.