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Where is Lisinopril-Hydrochlorothiazide used?

Lisinopril-Hydrochlorothiazide is a combined prescription used to treat hypertension or high blood pressure. This product contains two medications:

  • Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor that blocks a substance in the body that causes blood vessels to tighten. This relaxes the blood vessels that lower blood pressure as well as increasing the supply of oxygen and blood to the heart.
  • Hydrochlorothiazide is a thiazide diuretic (water pill) that lessens the amount of water in the body by increasing the flow of urine. As a result, it helps to lower blood pressure.

This is an FDA-approved prescription that comes as a tablet for oral use. Lisinopril-Hydrochlorothiazide is used when one drug is not controlling your blood pressure.

How does Lisinopril-Hydrochlorothiazide work?

Lisinopril blocks the action of a compound in the body called angiotensin-converting enzyme (ACE). Usually, ACE creates another compound called angiotensin II as part of the body’s natural control of blood pressure. Angiotensin II causes blood vessels to tighten and narrow which increases the pressure within the blood vessels. As Lisinopril blocks the action of ACE, it decreases the production of angiotensin II. This means that the blood vessels are allowed to widen and relax. The overall effect of this is a drop in blood pressure.

Hydrochlorothiazide is a diuretic that takes away extra fluid from the body by increasing the production of urine. Diuretics act in the kidneys. It works by causing the kidneys to increase the number of salts like sodium and potassium. These are filtered out of the blood and into the urine. When these are filtered out of the blood by the kidneys, they draw water along with them. As diuretics increase the removal of salts from the blood, they also cause more water to be drawn out of the blood and into the urine. Removing water from the blood reduces the volume of fluid circulating through the blood vessels. This subsequently lessens the pressure within the blood vessels.

How is Lisinopril-Hydrochlorothiazide taken?

Lisinopril-Hydrochlorothiazide is usually taken once a day in the morning or as directed by your doctor. If this medication causes you to urinate more frequently, it is best to take at least 4 hours before your bedtime. It is to prevent having to get up to urinate. Your doctor may give you a low starting dose and slowly increase it. You may take each dose with or without food. Take this medication by mouth with a full glass of water.

What are the possible side effects of Lisinopril-Hydrochlorothiazide?

  • Light-headedness
  • Dizziness
  • Headache as your body adjusts to the medication
  • Blurred vision
  • Dry cough
  • Constipation
  • Diarrhea
  • Upset stomach

Call your doctor if you have serious side effects such as:

  • A decrease in vision or eye pain
  • Fainting
  • Unusual change in the amount of urine

What are the precautions in taking Lisinopril-Hydrochlorothiazide?

  • Before using this medication, let your doctor know if you ever had an allergic reaction to it.
  • If you have any medical history, especially blood filtering procedures or desensitizing treatment for lupus, kidney, and liver disease.
  • Do not use any machinery or do anything the needs your alertness. This drug may make you dizzy. Do it until you know you can do it safely.
  • This may make you more sensitive to the sun. It may as well increase your risk of skin cancer. Limit your time in the sun and use sunscreen or wear protective clothing when outdoors.
  • This should not be used in children, pregnancy, breastfeeding women, and those with kidney failure who need dialysis.
  • Do not share this product or any of your medications with others.