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Ketotifen Fumarate

Ketotifen Fumarate is used for the treatment of inflammation of the eyes due to hay fever. It is also called seasonal allergic conjunctivitis. This prescription is usually used in adults and children aged 3 years and older. 

Seasonal allergic conjunctivitis

This usually happens when the eye of a person comes into contact with an allergen. Allergens are a substance that makes the immune system of the body overreact. The eye becomes inflamed and sore. Symptoms happen because the overreacting immune system makes the body release histamine and other active substances through mast cells. The blood vessels dilate or expand. By dilating or expanding, it irritates the nerve endings. The result is an increased secretion of tears.

Most people with seasonal allergic conjunctivitis have problems with both eyes. Symptoms may appear quickly, soon after the eyes come into contact with the allergen. In other cases, symptoms may appear after 2 to 4 days. Symptoms of seasonal allergic conjunctivitis include:

Red or pink eyes – the eyes become irritated as the capillaries or small blood vessels widen in the conjunctiva.

Itchiness – as the eyes are irritated, they may itch. Rubbing can make the itchiness worse.

Pain – this may affect one or both eyes. If a person has painful eyes and is sensitive to light, they should see a doctor at once.

Soreness – the inflammation may make the whole area feel sore and tender. Some people say the soreness feels like burning.

Swollen eyelids – the eyelids may puff up when the conjunctiva becomes inflamed or if the person has been rubbing them a lot.

People with seasonal allergic conjunctivitis will experience symptoms at certain times during the year. Usually, it is from early spring into summer and sometimes into fall. Those with this type of condition are susceptible at any time of year. They may find symptoms are worse at certain times of the day than at others. If the eyelids are red, dry, or cracked this may indicate contact conjunctivitis. Contact conjunctivitis and giant papillary conjunctivitis are not seasonal and symptoms may occur at any time of year. 

How It Works

Ketotifen Fumarate is a type of medicine called an antihistamine. This works by preventing the actions of histamine. Histamine is a substance produced by the body as part of its defense mechanisms. It is stored in cells called mast cells in almost all tissues of the body. When the body reacts to a foreign substance, the mast cells stimulated by the allergen release their stores of histamine. The released histamine then binds to its receptors which cause a chain reaction. Wherein, it results in allergic symptoms. It causes an increase in blood flow to the area of the allergy and the release of other chemicals that add to the allergic response. This results in the symptoms of an allergic reaction. 

In seasonal allergic conjunctivitis, histamine causes eye symptoms by acting on H1 receptors in the eyes. Ketotifen Fumarate blocks H1 histamine receptors in the eyes and thus stops these effects of histamine. 

How To Use

Apply one drop to the affected eye/s usually twice a day or as directed by your doctor. The dosage is based on your condition and response. 

To apply the medicine, wash your hands first. It is to avoid contamination. Do not touch the tip of the dropper or let it touch your eye or any other surface. Tilt your head back, look upward, mad pull down the lower eyelid. Hold the dropper and apply one drop in the lower eyelid. Look downward and slowly close your eyes for at least 1-2 minutes. Try not to blink and do not rub your eye. Do not rinse the dropper. Replace the dropper cap after each use and keep the bottle tightly closed.

If your doctor has prescribed this medication, use it regularly in order to get the most benefit from it. To help you remember, use it at the same time each day. Continue to use this medication as prescribed until you are no longer exposed to the allergic substance. If your condition persists or worsens, seek immediate medical attention. Ask your doctor if you can wear contact lenses while you are being treated with this medication. If your doctor says you may continue wearing them, remove them before using the eye drops, and wait at least 10 minutes after each dose before putting them again. Do not use this medication to treat irritation from contact lens wear. Consult your doctor about the use of contact lenses when the eyes are irritated or red.

Side Effects

  • Eye dryness
  • Stinging, burning, or irritation of the eye
  • Stuffy or runny nose
  • Headache
  • Increased sensitivity to light
  • Bad taste in your mouth 

Tell your doctor if you have unlikely but serious side effects:

  • Vision problems
  • Eye pain
  • Increased redness or swelling of the eye 


  • Ketotifen Fumarate is for use in the eyes only and must not be taken by mouth. 
  • These eye drops may cause your vision to blur temporarily after you have put the drops in your eyes. Do not drive or operate machinery until this has worn off.
  • Ketotifen Fumarate should be discarded four weeks after the bottle is first opened. The medicine could be contaminated with dirt or germs that could cause eye infections. Take note of the date of opening on the bottle so you know when to throw them away. Dispose of them carefully. 
  • This should not be used in children under 3 years of age. 
  • Ketotifen Fumarate should not be used if you are allergic to any of its ingredients. Please inform your doctor if you have previously experienced such an allergy. Stop using this medicine and inform your doctor right away if you feel you have experienced an allergic reaction.
  • Although only small amounts of this medicine pass into the bloodstream, the safety of this medicine for use in pregnancy is highly observed. This should be used with caution only if the benefits to the mother outweigh any risks to the developing. Seek further medical advice from your doctor before using this eye drops if you are pregnant.