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Juluca (Dolutegravir and Rilpivirine)

General Information

Juluca (Dolutegravir and Rilpivirine) is indicated to help control HIV infection. It is the type of infection that can cause the acquired immunodeficiency syndrome (AIDS). This helps to decrease the amount of HIV in your body. It is to help your immune system work well. This lowers your chance of getting HIV complications like cancer or new infections. This medication will also help you improve your quality of life.


How does Juluca (Dolutegravir and Rilpivirine) work?

Juluca (Dolutegravir and Rilpivirine) is an HIV-1 antiviral agent. It inhibits HIV integrase by binding to the active site. It also blocks the strand transfer step of retroviral DNA integration in the host cell. The strand transfer step is essential in the HIV replication cycle and results in the inhibition of viral activity.


Why use Juluca (Dolutegravir and Rilpivirine)?

Juluca Tablets is a fixed-dose combination containing Dolutegravir and Rilpivirine. These ingredients are integrase inhibitor and a non-nucleoside reverse transcriptase inhibitor (NNRTI). Both medications block the virus from developing and infecting more cells. Dolutegravir sodium is a white to light yellow powder and is slightly soluble in water. Rilpivirine hydrochloride is a white to almost white powder. It is practically insoluble in water.

This is available as tablets for oral administration. Each film-coated tablet has 50mg of Dolutegravir and 25mg of Rilpivirine. The Food and Drug Administration (FDA) has approved this medication already.

How to use Juluca (Dolutegravir and Rilpivirine)?

The recommended dosage is based on your medical condition and response to the drug.

This is to be taken by mouth with a full glass of water. It is usually taken once a day. You should take it with a meal as directed by your doctor. Take this medication at evenly spaced times for the best effects. To help you remember, take this at the same time each day.

What are the side effects of Juluca (Dolutegravir and Rilpivirine)?

Common side effects:

  • Headache
  • Diarrhea

If there are some unusual side effects that occur, call your doctor right away.

Warnings and Precautions

  • This medication is not a cure for HIV infection. To decrease the possibility of spreading HIV disease to others, do the following:
  • Continue to take all HIV medications exactly as it is prescribed
  • Always use an effective barrier method during all sexual activity
  • Do not share personal items that may have contacted blood or other body fluids (toothbrush, razors, or syringes)
  • If you are a pregnant or breastfeeding women, you should consult your doctor first.
  • Keep this medication away from the reach of children.