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Goserelin Acetate

Where is Goserelin Acetate used?

Goserelin Acetate is in the class of medication called gonadotropin-releasing hormone (GnRH) agonists. This is used;

  • To treat advanced breast cancer in certain women 
  • To manage endometriosis
  • To help with the treatment of abnormal bleeding of the uterus 
  • Alone to treat symptoms associated with advanced prostate cancer
  • In combination with other medications and with radiation therapy to treat localized prostate cancer 

How does Goserelin Acetate work?

Several prostate cancers want supplies of the male hormone testosterone to develop. Testosterone is an androgen made by the testes and adrenal glands. The making of testosterone can be stopped by surgically eliminating the testicles or by medication therapy. A hormone called luteinizing hormone (LH) that is produced by the pituitary gland. It stimulates the production of testosterone by the testicles. Agonists of the LH releasing hormone stop the production of luteinizing hormone by the pituitary gland. This lessens the production of testosterone in men. The cancer cells might then develop more slowly or stop increasing totally. Goserelin Acetate is a type of LHRH agonist.

How is Goserelin Acetate used?

Goserelin Acetate comes as an implant to be inserted with a syringe subcutaneously or under the skin. It is usually implanted in your stomach area given by a doctor or nurse in a medical office or clinic. An implant with 3.6 mg of this drug is usually inserted every 4 weeks. An implant with 10.8 mg is usually inserted every 12 weeks. The length of your treatment depends on the condition being treated and your response to the medication. Your doctor will determine how long you should use Goserelin Acetate.

Goserelin Acetate may cause an increase in certain hormones in the first few weeks after insertion of the implant. Your doctor will monitor you carefully for any new or worsening symptoms during this time. 

What are the possible side effects of Goserelin Acetate?

There are several things you can do to manage the side effects of this medication. Some of the side effects are:

  • Sweating
  • Hot flashes
  • Dizziness
  • Headache 
  • Vaginal dryness, itching, or discharge 
  • Mood changes 
  • Impotence
  • Increased or decreased interest in sex 
  • Breast swelling or tenderness
  • Fewer erections than normal
  • Nausea
  • Bone pain
  • Diarrhea
  • Vomiting
  • Loss of appetite
  • Constipation 
  • Sleep problems or insomnia
  • Mild skin rash or itching
  • Acne 

Call your doctor if you have these side effects:

  • Difficult or painful urination 
  • Bruising, pain, redness, swelling, bleeding, or oozing where the implant was injected
  • Nerve problems 
  • High calcium levels
  • High blood sugar 
  • Signs of a stroke 

What are the precautions in using Goserelin Acetate?

  • Tell your doctor if you are allergic to this drug or if you have any allergies,
  • What prescriptions you are taking or any other medicines including vitamins or herbal supplements, 
  • If you have a history of drinking alcohol or using tobacco products for a long period,
  • If you have ever had diabetes, compressed spinal cord, urinary obstruction in men, or heart disease,
  • If you are a pregnant or breastfeeding woman. This should not be used in pregnant except for the treatment of advanced breast cancer.