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Where is Enasidenib used?

Enasidenib is an isocitrate dehydrogenase-2 inhibitor that is used to treat acute myeloid leukemia (AML) with an isocitrate dehydrogenase-2 (IDH2) mutation. This medicine is used in patients who have not responded to other treatments or in those whose cancer has come back after treatment. Enasidenib helps block the enzyme isocitrate dehydrogenase which is needed by the cancer cells to grow. The US Food and Drug Administration has approved this prescription for medical use. 

How does Enasidenib work?

Enasidenib targets and blocks the IDH-1 enzyme. In several cancers, this receptor is overactive that causes cells to develop and split too quickly. By preventing these, this medication can slow or stop the growth of the tumor.

This medicine is a targeted therapy that uses small molecules that can get into the cell and disrupt the function of the cells that causes them to die. It also focuses on the inner parts of the cells and the outside of the cell. Therapies that target receptors are also known as monoclonal antibodies. Antiangiogenesis inhibitors aim at the blood vessels that supply oxygen to the cells, eventually initiating the cells to starve. 

How is Enasidenib taken?

  • Use this medication exactly as directed by your doctor. Do not use it more often, do not use more of it, and do not use it for a longer period than your doctor recommended.
  • Swallow the tablet as a whole with a glass of water. Do not chew, crush, or break it.
  • Take this drug at the same time each day. 
  • Each medicine may be taken either with or without food.
  • The amount of medicine that you take depends on the strength of the medicine, your overall health, and the condition being treated. 
  • The usual dosage for this treatment in adults is 100 milligrams taken once a day. Your doctor might adjust the dosage when needed. 

What are the possible side effects of Enasidenib?

  • Headache
  • A general feeling of illness
  • Muscle or joint pain
  • Nausea
  • Sore throat
  • Light-headedness
  • Dizziness
  • Chest or bone pain
  • Cough
  • Decreased awareness or responsiveness
  • Fever
  • Rapid weight gain
  • Pale skin

Several side effects may befall that typically do not need medical attention. These side effects may go away during treatment as your body adjusts to the drug. Similarly, your doctor may be able to tell you about ways to prevent or lessen some of these side effects. 

What are the precautions in taking Enasidenib?

  • Do not take other medications unless they have been discussed with your doctor. This includes non-prescription or prescription medicines as well as or vitamin herbal supplements.
  • Inform your doctor if you are pregnant or may be pregnant before starting this treatment. The use of this medicine in pregnancy may cause fetal harm. 
  • Do not breastfeed while taking Enasidenib.
  • Avoid sun exposure. Wear protective clothing when going outside.
  • Avoid people who recently have been vaccinated or with any type of infection.
  • While you are taking this medicine, you will be checked regularly by your doctor. It is to monitor side effects and check your response to therapy.