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Edoxaban

What condition does Edoxaban treat?

Edoxaban is used to prevent serious blood clots from forming caused by a certain irregular heartbeat known as atrial fibrillation. This drug may also be used to treat certain blood clots such as in pulmonary embolus (PE) or deep vein thrombosis (DVT).

This medicine is a factor Xa inhibitor. This is supplied as Edoxaban tosylate monohydrate film-coated tablets for oral use. This has been already approved by the Food and Drug Administration (FDA).

How does Edoxaban work?

Edoxaban is a selective inhibitor of FXa. It does not need an anti-thrombin III for antithrombotic activity. This drug prevents permitted FXa and prothrombinase movement. It also inhibits thrombin-induced platelet accumulation. Inhibition of FXa in the coagulation cascade decreases thrombin generation. It also reduces thrombus formation. This medication works by blocking certain clotting proteins in your blood.

What is the recommended dosage of Edoxaban?

The recommended dosage is based on your medical condition and response. For children, the dosage may also be based on their weight.

The usual dose of this medicine is 60 mg a day. Your doctor may prescribe 30 mg a day if you:

  • Have a low body weight
  • Have kidney disease
  • Are taking dronedarone used to treat atrial fibrillation
  • Are taking ciclosporin used to treat psoriasis and rheumatoid arthritis
  • Are taking erythromycin or ketoconazole used to treat fungal or bacterial infections

If you are not sure what dose you need to take, check with your doctor. The medicine is to be taken by mouth with a full glass of water. Use this prescription regularly to get the most benefit from it. Take it at the same time every day to help you remember

Do not stop taking this drug without consulting your doctor. Your condition may become worse when this medication is suddenly stopped. Follow the prescription of your doctor carefully.

What are the side effects of Edoxaban?

  • Easy bruising
  • Bleeding
  • Rash
  • Nosebleed
  • Abnormal liver function tests
  • Low red blood cell count (anemia)

Call for medical help if there are signs of an allergic reaction:

  • Difficult breathing
  • Hives
  • Swelling of your face, tongue, lips, throat

What are the precautions in taking Edoxaban?

  • Before taking this drug, tell your doctor if you are allergic to it or you have any allergies. This may contain inactive ingredients which can cause an allergic reaction.
  • Tell your doctor if you have any medical history or current medications.
  • This medication should only be used when needed for pregnant women. Call your doctor right away if you get pregnant while taking this medicine.
  • It is unknown if this passes to breast milk. Consult your doctor first before breastfeeding.
  • If you ever had a blood clot (pulmonary embolism or DVT) you’ll normally take this medication for at least 3 months. It depends on what caused the blood clot. You might need to take it for longer.
  • If you have atrial fibrillation you might need to take this medication long-term or even for the rest of your life.
  • Ask your doctor for advice straight away as taking too much of this drug puts you at risk of bleeding.