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Darunavir-Cobicistat

Where is Darunavir-Cobicistat used?

Darunavir-Cobicistat is an FDA-approved combined medication used to control HIV infection. This is used with other HIV medications to help control the infection. This helps to lessen the amount of HIV in your body so your immune system can work better. This also lowers your chance of getting HIV complications and improves your quality of life.

How does Darunavir-Cobicistat work?

An enzyme produced by HIV called protease plays an important role. Protease breaks up new protein produced by the virus so that new copies of the virus can be assembled from the pieces. When this enzyme is not working, some new virus that is made is damaged and incapable of infecting more CD4 cells. Darunavir is in the class of medications called protease inhibitors that works by stopping the protease enzyme from working.

Cobicistat is a type of medicine called a pharmacokinetic enhancer that is used to increase the levels of Darunavir. It slows the breakdown of Darunavir by the liver which makes it stay in the body for longer. This increases the level of Darunavir in the blood and its effects against the virus. This medication helps the immune system to recover. Therefore, it slows down or stops the progression of the disease from HIV to AIDS.

How is Darunavir-Cobicistat taken?

Darunavir-Cobicistat is usually taken once a day as directed by your doctor. The recommended dosage is based on your overall medical condition and response to the treatment. It is important to continue taking this medication exactly as it is prescribed. Do not skip any doses.

Your doctor may direct you to start at a lower dose and gradually increase it. Do not suddenly stop taking this medication without consulting your doctor. To help you remember, take it at the same time and in the same way each day.

What are the possible side effects of Darunavir-Cobicistat?

  • Nausea
  • Diarrhea
  • Headache
  • Vomiting
  • Cough
  • Abdominal pain
  • Loss of appetite
  • Tiredness
  • Dizziness
  • Muscle soreness
  • Fatigue
  • Stomach upset

What are the precautions in taking Darunavir-Cobicistat?

  • Follow carefully the instructions of your doctor while taking anti-HIV medicines to maintain effective levels of the drugs in your blood. If the blood levels of the medicines drop, the virus will be given more chances to replicated and develop resistance to the drugs. Skipping even a few doses increases the risk of treatment failure.
  • You may experience an increased level of sugar in fats in your blood while having this medication.
  • Darunavir-Cobicistat is not recommended to use if you are allergic to it or if you ever had an allergic reaction to it. Inform your doctor if you have any allergies before taking a dose of this drug.
  • This product should be used with caution in people over 65 years of age. Also, use this carefully in people with diabetes, mild to moderately decreased liver function, blood clotting disorder, or liver disorders.
  • The safety and effectiveness of this drug have not been studied in children and adolescents under 18 years of age. Therefore, this is not recommended for use, in this age group.