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Cycloserine

Where is Cycloserine used?

Cycloserine is used to treat tuberculosis (TB). This is used in combination with other medications. In some cases, this may also be used to treat urinary tract infections (UTIs). This will not work for viral infections like flu or common colds. Misuse or unnecessary use of any antibiotic may cause decreased effectiveness.  

This is a broad-spectrum antibiotic that is produced by a strain of Streptomyces orchidaceous. It has also been synthesized. The Food and Drug Administration (FDA) has approved this treatment.

How does Cycloserine work?

Cycloserine is similar in structure to the amino acid d-alanine. It interferes with an early step in bacterial cell wall synthesis in the cytoplasm. It is by competitive inhibition of two enzymes called L-alanine racemase that forms D-alanine and D-alanylalanine synthetase. Wherein, it includes D-alanine into the pentapeptide needed for the formation of peptidoglycan. It also incorporates bacterial cell wall synthesis. Wherein, it kills the bacteria.

How is Cycloserine taken?

The recommended dosage for this medication depends on your medical condition, weight, and response to the treatment.

This medicine is to be taken by mouth with a full glass of water. It is usually taken twice a day every 12 hours or as directed by your doctor. Do not take more than 1000 mg per day. If this medicine interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medication, check with your healthcare provider.

Antibiotics work best when the amount of the drug in your body is kept at a constant level. You should take this medication at evenly spaced intervals. Follow your doctor’s prescription very carefully to get the most benefit of this treatment. Do not change your dosage unless the doctor tells you to do so.

What are the possible side effects of Cycloserine?

  • Drowsiness
  • Irritability
  • Dizziness
  • Mood changes
  • Headache
  • Difficulty speaking

What are the precautions in taking Cycloserine?

  • This is not prescribed for those who have suffered from depression, those who have epilepsy, and have kidney disease.
  • Avoid dangerous activity or driving until you know how this medicine will affect you. Your responses could be impaired.
  • Do not receive any vaccinations or immunizations while using this medication.
  • Avoid drinking alcohol. It may increase your risk of seizures or other side effects.
  • This should be used only when needed during pregnancy. Call your doctor right away if you get pregnant while having this treatment.
  • If you are breastfeeding women, consult your doctor first. Do not take a dose of this medicine if you are breastfeeding without advice from your doctor.
  • Let your doctor know if you have any allergies and current treatments or medications. Tell also your doctor if you have any medical history.
  • It is important to inform your doctor if you have a condition that causes fits or you have mental health problems such as depression or anxiety. Also, tell your doctor if you ever had a rare inherited blood disorder called porphyria.
  • Keep this away from moisture and heat.