Aggrastat (Tirofiban HCI) is indicated to lessen the rate of thrombotic cardiovascular events. It is a combined endpoint of death, myocardial infarction or refractory ischemia cardiac procedure. This is used in patients with non-ST elevation acute coronary syndrome.
Aggrastat is a non-preserved, clear, isosmotic and sterile premixed injection. It also has a sodium chloride for tonicity adjustment.
Why use Aggrastat (Tirofiban HCI)?
Aggrastat contains tirofiban hydrochloride. It is a non-peptide antagonist of the platelet GP IIb/IIIa receptor. It inhibits the aggregation of platelets. This is white to off-white, free-flowing powder, and non-hygroscopic. This is supplied as a sterile solution in water for intravenous use. The Food and Drug Administration (FDA) has approved this medication. You can buy this here at its very affordable price.
How does Aggrastat (Tirofiban HCI) work?
Aggrastat (Tirofiban HCI) is a reversible antagonist of fibrinogen binding to the GP IIb/IIIa receptor. It is the main platelet surface receptor involved in platelet aggregation. When managed intravenously, this treatment prevents ex vivo platelet aggregation in a dose. It also inhibits in a concentration-dependent manner.
Aggrastat prevents platelet function as demonstrated by its ability to inhibit:
- prolong bleeding time in healthy subjects
- ex vivoadenosine phosphate (ADP)-induced platelet aggregation
- patients with coronary artery disease
The time progression of inhibition matches the plasma absorption profile of the drug.
How to use Aggrastat (Tirofiban HCI)?
The dose of this treatment will base on the patient’s condition and weight. This medication is usually administered for at least 48 hours. This is for those who have had a heart attack or who have unstable angina. This is given by injection. To avoid complications, do not double the given dosage.
What are the side-effects of Aggrastat (Tirofiban HCI)?
- Swelling or pain at the injection site
- Signs of severe allergic reaction (hives, trouble breathing, swelling)
- Decreased in cell platelets
- Bleeding from any wounds
If these continue or worsen, call your doctor right away.
Warnings and Precautions
- Before using this treatment, inform your doctor if you have any allergies, current medications or medical history.
- This is not prescribed for pregnant women. If you are breastfeeding women, you should stop it while having this treatment. You may continue after 24 hours after treatment has been stopped.
- If you have any infections at the injection site, consult it to your doctor.
- Keep this away from the reach of children.