Adriamycin PFS (Doxorubicin Hydrochloride) is indicated as a component of multi-agent adjuvant chemotherapy. This is for the treatment of women with axillary node involvement following resection of primary breast cancer. This is also indicated for the treatment of:
- Acute lymphoblastic/myeloblastic leukemia
- Hodgkin/non-Hodgkin lymphoma
- Metastatic breast cancer
- Metastatic bone sarcoma/soft tissue
- Metastatic ovarian carcinoma
Why use Adriamycin PFS (Doxorubicin Hydrochloride)?
Adriamycin PFS contains Doxorubicin which is a cancer medication. It interferes with the growth and spread of cancer cells in the body. This is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius. This is supplied in the hydrochloride form as a sterile red-orange lyophilized powder. This has lactose and as a sterile parenteral, isotonic solution with sodium chloride for intravenous use. The Food and Drug Administration (FDA) has approved this medication.
How does Adriamycin PFS (Doxorubicin Hydrochloride) work?
The cytotoxic effect of doxorubicin on malignant cells and its toxic effects on various organs are thought to be related to nucleotide base intercalation. The cell membrane lipid binding activities are also related. Intercalation inhibits nucleotide base intercalation. It also includes the action of DNA and RNA polymerases. The interaction of this medicine with topoisomerase II to form DNA-cleavable complexes appears to be an important mechanism of doxorubicin cytocidal activity.
How to use Adriamycin PFS (Doxorubicin Hydrochloride)?
This is injected into a vein through an IV. Your doctor or healthcare provider will give you this treatment. The dosage will depend on your medical condition and response to the treatment.
What are the side-effects of Adriamycin PFS (Doxorubicin Hydrochloride)?
- Missed menstrual periods
- Blisters, pain, or skin sores at the injection site
- Easy bruising or unusual bleeding
The list above is not the complete list of the side effects. If there is another side effect that happens and if it persists or worsens, call your doctor right away.
Warnings and Precautions
- Consult your doctor first if you are pregnant or breastfeeding before using this treatment.
- Do not share your medications with others who have the same condition as yours.
- If an allergic reaction happens, contact your doctor right away.
- If you have open wounds or infections at the injection site, do not use this without consulting.
- Avoid applying pressure at the injection site.
- Apply ice to the site intermittently for 15 minutes 4 times a day for 3 days.
- Keep all your medications far from the reach of children or pets.